Painful Discharge

newyorker: Cartoon by J.C. Duffy. For...

Wed, 03 Apr 2013 08:24:52 -0400

newyorker:

Cartoon by J.C. Duffy. For more: http://nyr.kr/13MVoBY

tosort: For a Successful Convention- Columbus Ohio and The Neil...

Sun, 31 Mar 2013 14:58:35 -0400

tosort:

For a Successful Convention- Columbus Ohio and The Neil House (RIP)

newyorker: Cartoon by Zachary Kanin. For...

Sun, 31 Mar 2013 14:57:15 -0400

newyorker:

Cartoon by Zachary Kanin. For more: http://nyr.kr/13Ewa8J

newyorker: Cartoon by Emily Flake. For more from this week’s...

Sun, 31 Mar 2013 14:56:47 -0400

newyorker:

Cartoon by Emily Flake. For more from this week’s issue: http://nyr.kr/10gOgb1

NIH on Flickr.I get a lot more respect away from campus.

Thu, 07 Mar 2013 15:42:18 -0500

NIH on Flickr.

I get a lot more respect away from campus.

a brief second of neuroscience on Bob’s Burgers

Mon, 04 Mar 2013 08:43:51 -0500

a brief second of neuroscience on Bob’s Burgers

Electrodes on Flickr.

Fri, 01 Mar 2013 19:17:16 -0500

Electrodes on Flickr.

it8bit: Long Exposures of 80s Video Games Created by Rosemarie...

Mon, 25 Feb 2013 19:34:39 -0500

it8bit:

Long Exposures of 80s Video Games

Created by Rosemarie Fiore

(via: Retroist)

I recognize these…

neuromorphogenesis: 5-ALA fluorescence guides resection of...

Thu, 21 Feb 2013 17:01:07 -0500

neuromorphogenesis:

5-ALA fluorescence guides resection of recurrent glioblastoma multiforme

Neurosurgeons from UC San Francisco describe the use of 5-aminolevulinic acid (5-ALA) fluorescence in guiding resection of recurrent glioblastoma multiforme (GBM). Ingestion of 5-ALA by a patient before surgery leads to fluorescence of tumor cells intraoperatively in response to certain wavelengths of light. This can provide information not necessarily available through magnetic resonance imaging (MRI), the standard mode of imaging used to detect primary and recurrent GBMs. The additional information provided by 5-ALA fluorescence can guide surgeons in the treatment of individual cases.

The case of a 56-year-old man is described in the article “Subependymal spread of recurrent glioblastoma detected with the intraoperative use of 5-aminolevulinic acid. Case report,” by Tene A. Cage, M.D., Melike Pekmezci, M.D., Michael Prados, M.D., and Mitchel S. Berger, M.D., published today online, ahead of print, in the Journal of Neurosurgery. The patient presented with frequent transient visual disturbances. Seven years earlier, he had undergone gross-total (maximum) resection of a GBM located in the right occipital lobe. A new MRI study was performed and the images showed three distinct, new sites of tumor in the man’s right temporal lobe. There was no evidence of recurrent tumor at the site where the original tumor had been located.

Glioblastoma multiforme (GBM) is the most common primary tumor of the brain. It is extremely aggressive and is usually treated with resection followed by chemotherapy and radiotherapy. Even using this treatment, patient survival is not long: on average 1 to 2 years. The authors note that the best way to lengthen survival is to remove as much tumor as possible. This holds for recurrent GBM as well as for the initial tumor.

The patient in this case was scheduled for surgery to remove the three new lesions. To aid in visualization of the lesions intraoperatively, the neurosurgical team, led by Mitchel S. Berger, M.D., Chairman of the Department of Neurological Surgery at UC San Francisco, administered 5-ALA to the patient four hours prior to surgery. During surgery, a blue light was used to activate 5-ALA fluorescence of tumor cells and thus differentiate tumor from other brain tissue. Using the blue light, the surgeons were able to detect tumor cells along the lining of the right lateral ventricle, in the ependymal and subependymal regions. Although the appearance of the three lesions on preoperative MRI had indicated distinct sites of recurrent disease (multicentric tumor recurrence), the fluorescence of tumor cells during surgery mapped out the spread of disease from the original GBM site in the right occipital lobe to three sites in the right temporal lobe through a pathway along the wall of the right ventricle. This showed that the GBM recurrence was not multicentric at all. The fluorescence also made it possible for the surgeons to identify and resect additional tumor tissue along the pathway between the original and recurrent lesions.

According to the authors, MRI is unable to clearly delineate diffuse tumor infiltrating the ependyma and subependymal zone lining the lateral ventricle. Addition of 5-ALA fluorescence during surgery revealed the pathway of tumor spread through these regions.

With recurrent GBM, it is valuable to distinguish whether the recurrence is multicentric disease or infiltrative disease extending from the original tumor. According to Dr. Berger, “Multicentric disease can add a worse prognosis. Finding it during surgery is important and can influence the extent of resection.” Addition of 5-ALA fluorescence has been identified as substantially increasing the success of achieving maximum resection. Dr. Berger says that intraoperative use of 5-ALA “could be useful in all GBM cases.”

thezissouteam: St. Vincent covers Bob’s Burgers song

Tue, 12 Feb 2013 18:49:39 -0500

thezissouteam:

St. Vincent covers Bob’s Burgers song

Watermelons invite mirthful companionship.

Tue, 05 Feb 2013 11:53:40 -0500

Watermelons invite mirthful companionship.

musicbabes: David Carroll - Percussion Parisienne

Sat, 02 Feb 2013 15:56:28 -0500

musicbabes:

David Carroll - Percussion Parisienne

If you identify with this conundrum perhaps...

Wed, 30 Jan 2013 23:03:52 -0500

If you identify with this conundrum perhaps it…
tumblr.com

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If you identify with this conundrum perhaps it would be worth displaying this image, as a print, near the site of greatest offense. Happy Wednesday to you all!
Posted on January 30, 2013 with 1,190 notes

Successful and Schizophrenic - NYTimes.com

Mon, 28 Jan 2013 23:12:58 -0500

Successful and Schizophrenic - NYTimes.com:

(via Instapaper)

creepingirrelevance: speed dial

Sat, 26 Jan 2013 23:37:03 -0500

creepingirrelevance:

speed dial

tosort: Cover of a book from the Central Youth and Sport Club...

Fri, 25 Jan 2013 16:01:43 -0500

tosort:

Cover of a book from the Central Youth and Sport Club of Berlin. c.a. 1966

I think this is the Germany I always dreamed of.

Liberal Arts Education for Humility

Fri, 18 Jan 2013 20:57:00 -0500

Liberal Arts Education for Humility:

Interesting. I always tell my incoming students that they more you know the more you know that you don’t know. So, yeah, sort of like this.

(via Instapaper)

myjetpack: YOU’RE ALL JUST JEALOUS OF MY JETPACKwill be...

Thu, 10 Jan 2013 09:25:11 -0500

myjetpack:

YOU’RE ALL JUST JEALOUS OF MY JETPACK
will be published as a book this year by Drawn & Quarterly.

Many of the cartoons from this tumblr will be in the book, some will not be (because I did them after the selection was made) and there will be many others in the book which have not appeared on tumblr.

Some more details (including pre-order links) are at http://www.tomgauld.com/index.php?/shop/jetpack/

Hooray!

fer1972: Hand and Brain by Kristian Hammerstad

Mon, 07 Jan 2013 22:46:28 -0500

fer1972:

Hand and Brain by Kristian Hammerstad

Neuroscience Fiction

Mon, 07 Jan 2013 00:07:15 -0500

Neuroscience Fiction:

(via Instapaper)